Phytocannabinoids Profile in Medicinal Cannabis Oils: The Impact of Plant Varieties and Preparation Methods

Cannabis ( L.) is a highly promising medicinal plant with well-documented effectiveness and growing use in the treatment of various medical conditions. Cannabis oils are mostly used in galenic preparations, due to their easy adjustment of the administration dose, together with the enhanced bioavaila...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in pharmacology Vol. 11; p. 570616
Main Authors Dei Cas, Michele, Casagni, Eleonora, Casiraghi, Antonella, Minghetti, Paola, Fornasari, Diego Maria Michele, Ferri, Francesca, Arnoldi, Sebastiano, Gambaro, Veniero, Roda, Gabriella
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 13.11.2020
Subjects
cannabinoids
chemometrics methods
medical cannabis
pharmaceutical chemistry
Pharmacology
phytochemistry
cannabinoids
chemometrics methods
medical cannabis
pharmaceutical chemistry
phytochemistry
Online AccessGet full text

Cover

More Information
Summary:Cannabis ( L.) is a highly promising medicinal plant with well-documented effectiveness and growing use in the treatment of various medical conditions. Cannabis oils are mostly used in galenic preparations, due to their easy adjustment of the administration dose, together with the enhanced bioavailability of its active compounds. As stated by the Italian Law (9/11/2015, 279 Official Gazette), "to ensure the quality of the oil-based cannabis preparation, the titration of the active substance(s) should be carried out." This study aims to represent the Italian panorama of cannabis oils, which were analyzed (8,201) to determine their cannabinoids content from 2017 to 2019. After application of the exclusion criteria, 4,774 standardized cannabis oils were included, which belong to different medicinal cannabis varieties and prepared according to different extraction methods. The concentration of the principal cannabinoids was taken into account dividing samples on the basis of the main extraction procedures and cannabis varieties. According to this analysis, the most substantial variations should be attributed to different cannabis varieties rather than to their extraction protocols. This study may be the starting point of preparatory pharmacists to assess the correct implementation of the preparation procedures and the quality of the extracts.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Reviewed by: Maurizio Servili, University of Perugia, Italy
This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology
Federica Pollastro, University of Eastern Piedmont, Italy
Edited by: William Chi-Shing Tai, Hong Kong Polytechnic University, Hong Kong
Sonia Gomes, University of Trás-os-Montes and Alto Douro, Portugal
Francesco Paolo Busardò, Sapienza University of Rome, Italy
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2020.570616