"Fruit in a tooth" - A rare non - Syndromic anomaly - 2 rare case reports with a genetic analysis

Tooth agenesis is one of the most common developmental anomalies affecting function and aesthetics. Genetic mutations cause non-syndromic tooth agenesis and involve the interaction of genes of tooth epithelium and mesenchyme odontogenesis. This article is the first in the literature to present non-s...

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Bibliographic Details
Published inJournal of Indian Academy of Oral Medicine and Radiology Vol. 34; no. 4; pp. 484 - 487
Main Authors Murugan, Arul, Anuradha, G, Kannan, A, Lakshmi, Krithika
Format Journal Article
LanguageEnglish
Published Mumbai Wolters Kluwer India Pvt. Ltd 01.10.2022
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Subjects
Analysis
Case reports
Epithelium
Gene mutations
Genetic analysis
Genetic aspects
Genetic disorders
Genetic research
Mesenchyme
Molars
Morphogenesis
Odontogenesis
genetic mutation
PAX9Key Message: Genes interact with the tooth epithelium and mesenchyme during their development
Developmental defect
mulberry molar
and genetic mutation can cause non-syndromic tooth anomalies and agenesis
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Summary:Tooth agenesis is one of the most common developmental anomalies affecting function and aesthetics. Genetic mutations cause non-syndromic tooth agenesis and involve the interaction of genes of tooth epithelium and mesenchyme odontogenesis. This article is the first in the literature to present non-syndromic cases of two siblings reported with mulberry molars, morphological changes in teeth (hypodontia and microdontia), and a genetic study performed to substantiate the involvement of Paired box gene 9 in tooth agenesis and morphogenesis.
ISSN:0972-1363
0975-1572
DOI:10.4103/jiaomr.jiaomr_84_22