A curious case of central odontogenic fibroma: A novel perspective

We appraise a case of central odontogenic fibroma (COF) with unusual histologic features of entrapped neural elements and mast cells. The presence of mast cells attributed to the release of stem cell factor, the principal growth and activating factor of mast cells. A putative role for C-kit and mast...

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Bibliographic Details
Published inJournal of oral and maxillofacial pathology : JOMFP Vol. 22; no. 4; pp. 16 - 19
Main Authors Chandrashekar, Chetana, Sen, Subhalakshmi, Narayanaswamy, Venkadasalapathi, Radhakrishnan, Raghu
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.01.2018
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Subjects
c-Kit protein
Calcification
Case Report
Fibroblasts
Fibromas
Higher education
Kinases
Mast cells
Pathogenesis
Pathology
Signal transduction
Stem cell factor
Stem cells
Teeth
Tumors
mast cells
C-kit
central odontogenic fibroma
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Summary:We appraise a case of central odontogenic fibroma (COF) with unusual histologic features of entrapped neural elements and mast cells. The presence of mast cells attributed to the release of stem cell factor, the principal growth and activating factor of mast cells. A putative role for C-kit and mast cells in the pathogenesis of COF is described.
ISSN:0973-029X
1998-393X
DOI:10.4103/jomfp.JOMFP_156_16