In Vitro Production of a Chemotactic Factor by Inflammatory SH-Dependent Protease from Rabbit and Human Immunoglobulin G Subclasses

Previously a chemotactic factor similar to an inflammatory factor (leucoegresin) was produced in vitro from natural IgG of man and rabbit by a neutral SH-dependent protease from inflammatory tissue. The enzyme induced a similar chemotactic generation of IgG subclasses of man and rabbit. The generati...

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Published inThe Tohoku Journal of Experimental Medicine Vol. 114; no. 1; pp. 49 - 54
Main Authors YAMAMOTO, SHUNSUKE, NISHIURA, MOTOSHI, MATSUMURA, KATSUMI
Format Journal Article
LanguageEnglish
Published Japan Tohoku University Medical Press 1974
Subjects
Animals
chemotactic factor
Chemotaxis
Chromatography, DEAE-Cellulose
Goats - immunology
Humans
Immunoelectrophoresis
immunoglobulin G
Immunoglobulin G - metabolism
In Vitro Techniques
leucocyte emigration
leucoegresin
Leukocytes - immunology
Micropore Filters
Molecular Weight
Myeloma Proteins - metabolism
Papain
Peptide Hydrolases - isolation & purification
Peptide Hydrolases - metabolism
protease
Rabbits - immunology
Structure-Activity Relationship
Sulfhydryl Compounds
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Summary:Previously a chemotactic factor similar to an inflammatory factor (leucoegresin) was produced in vitro from natural IgG of man and rabbit by a neutral SH-dependent protease from inflammatory tissue. The enzyme induced a similar chemotactic generation of IgG subclasses of man and rabbit. The generation of chemotactic substance was more pronounced from human IgG2 and IgG4 or rabbit fast-moving IgG than from human IgG1 and IgG3 or rabbit slow-moving IgG. The results suggested that the enzyme activity was influenced by some particular structural specificity of IgG molecules.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0040-8727
1349-3329
DOI:10.1620/tjem.114.49