Advances in proteomic phenotyping of microglia in neurodegeneration

Microglia are dynamic resident immune cells of the central nervous system (CNS) that sense, survey, and respond to changes in their environment. In disease states, microglia transform from homeostatic to diverse molecular phenotypic states that play complex and causal roles in neurologic disease pat...

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Published inProteomics (Weinheim) Vol. 23; no. 13-14; pp. e2200183 - n/a
Main Authors Sunna, Sydney, Bowen, Christine A., Ramelow, Christina C., Santiago, Juliet V., Kumar, Prateek, Rangaraju, Srikant
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.07.2023
Subjects
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Alzheimer's disease
Animal models
Animals
Central nervous system
Central Nervous System - pathology
Health risks
Humans
Immune system
inflammation
Microglia
neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - pathology
Neurological diseases
Pathogenesis
Phenotyping
Proteomes
Proteomics
Risk factors
signaling
Transcriptomes
Transcriptomics
neurodegeneration
signaling
proteomics
inflammation
microglia
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Summary:Microglia are dynamic resident immune cells of the central nervous system (CNS) that sense, survey, and respond to changes in their environment. In disease states, microglia transform from homeostatic to diverse molecular phenotypic states that play complex and causal roles in neurologic disease pathogenesis, as evidenced by the identification of microglial genes as genetic risk factors for neurodegenerative disease. While advances in transcriptomic profiling of microglia from the CNS of humans and animal models have provided transformative insights, the transcriptome is only modestly reflective of the proteome. Proteomic profiling of microglia is therefore more likely to provide functionally and therapeutically relevant targets. In this review, we discuss molecular insights gained from transcriptomic studies of microglia in the context of Alzheimer's disease as a prototypic neurodegenerative disease, and highlight existing and emerging approaches for proteomic profiling of microglia derived from in vivo model systems and human brain.
Bibliography:Srikant Rangaraju is senior author.
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ISSN:1615-9853
1615-9861
DOI:10.1002/pmic.202200183