Effects of dimethylsulfoxide (DMSO), nocodazole, and taxol on mast cell histamine secretion

Nocodazole depolymerized microtubules and increased the number of microfilaments, and dimethylsulfoxide increased the number of microfilaments. Both drugs inhibited compound 48/80-induced histamine release from rat mast cells. Taxol, which increased the number of microtubules, had no effect on hista...

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Bibliographic Details
Published inActa pharmacologica et toxicologica Vol. 59; no. 3; p. 214
Main Authors Nielsen, E H, Johansen, T
Format Journal Article
LanguageEnglish
Published Denmark 01.09.1986
Subjects
Alkaloids - pharmacology
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents, Phytogenic - pharmacology
Benzimidazoles - pharmacology
Dimethyl Sulfoxide - pharmacology
Histamine Release - drug effects
Immunochemistry
In Vitro Techniques
Male
Mast Cells - drug effects
Mast Cells - ultrastructure
Microtubules - drug effects
Nocodazole
Paclitaxel
Rats
Rats, Inbred Strains
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Summary:Nocodazole depolymerized microtubules and increased the number of microfilaments, and dimethylsulfoxide increased the number of microfilaments. Both drugs inhibited compound 48/80-induced histamine release from rat mast cells. Taxol, which increased the number of microtubules, had no effect on histamine release. These observations support the view that microtubules may not be directly involved in secretion, but apparently an increased number of microfilaments is associated with a decreased capacity of the mast cells for histamine release. We suggest that microfilaments have to be depolymerized or rearranged before secretion can take place.
ISSN:0001-6683
DOI:10.1111/j.1600-0773.1986.tb00157.x