Towards Proto-Cells: "Primitive" Lipid Vesicles Encapsulating Giant DNA and Its Histone Complex

An important prebiotic event was probably the incorporation of nucleic acids by lipid vesicles. This process was studied with artificial model cells and fluorescent probes. Pictures 1–4 represent a time series of fluorescence microscopic images of T4 DNA molecules (166 kb) incorporated into giant ve...

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Published inChembiochem : a European journal of chemical biology Vol. 2; no. 6; pp. 457 - 459
Main Authors Nomura, Shin-ichirou M., Yoshikawa, Yuko, Yoshikawa, Kenichi, Dannenmuller, Olivier, Chasserot-Golaz, Sylvette, Ourisson, Guy, Nakatani, Yoichi
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 01.06.2001
WILEY‐VCH Verlag GmbH
Subjects
Bacteriophage T4 - genetics
Diterpenes
DNA - chemistry
DNA - metabolism
DNA - ultrastructure
DNA structures
Fluorescent Dyes - metabolism
Lipids - chemistry
membranes
Microscopy, Confocal
Molecular Structure
Polyisoprenyl Phosphates - chemistry
prebiotic chemistry
single molecules
Transport Vesicles - chemistry
Transport Vesicles - metabolism
vesicles
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Summary:An important prebiotic event was probably the incorporation of nucleic acids by lipid vesicles. This process was studied with artificial model cells and fluorescent probes. Pictures 1–4 represent a time series of fluorescence microscopic images of T4 DNA molecules (166 kb) incorporated into giant vesicles of 5 μm diameter. The entrapped DNA molecules are in a coiled state.
Bibliography:ark:/67375/WNG-JKLL8S3M-3
ArticleID:CBIC457
istex:FC99EC4DB339BA6CC1604F4885C260F21FE898B8
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1439-4227
1439-7633
DOI:10.1002/1439-7633(20010601)2:6<457::AID-CBIC457>3.0.CO;2-F