Poor neuroleptic response in acutely exacerbated schizophrenic patients

Poor neuroleptic response is a major unresolved clinical problem. Precise data concerning the frequency of poor neuroleptic response are not available. The implementation of treatment modalities that are specifically recommended for non-responders (such as clozapine) increases the desirability of su...

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Bibliographic Details
Published inActa psychiatrica Scandinavica Vol. 87; no. 2; p. 86
Main Authors Shalev, A, Hermesh, H, Rothberg, J, Munitz, H
Format Journal Article
LanguageEnglish
Published United States 01.02.1993
Subjects
Adolescent
Adult
Aged
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - pharmacology
Dose-Response Relationship, Drug
Female
Hospitalization
Humans
Male
Middle Aged
Schizophrenia - drug therapy
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Summary:Poor neuroleptic response is a major unresolved clinical problem. Precise data concerning the frequency of poor neuroleptic response are not available. The implementation of treatment modalities that are specifically recommended for non-responders (such as clozapine) increases the desirability of such data. This study evaluated the proportion of acutely exacerbated schizophrenics who remained unimproved by consecutive administration of haloperidol, chlorpromazine and perphenazine, in randomly determined order. The overall improvement rate was 95%. The frequency of good responses to the first, second and third drug were 67%, 55%, and 67% respectively. Differences in receptor affinity profile might explain the added beneficial effect of a second or third drug.
ISSN:0001-690X
DOI:10.1111/j.1600-0447.1993.tb03335.x