Angiotensin II levels in hypertensive and normotensive pregnancies

• Published in: British journal of obstetrics and gynaecology Vol. 98; no. 2; p. 155
• Main Authors: Hanssens, M, Keirse, M J, Spitz, B, van Assche, F A
• Format: Journal Article
• Language: English
• Published: England 01.02.1991
• Subjects: Angiotensin II - blood; Female; Humans; Hypertension - blood; Pregnancy - blood; Pregnancy Complications, Cardiovascular - blood
• ISSN: 0306-5456; 1365-215X
• DOI: 10.1111/j.1471-0528.1991.tb13361.x

We measured circulating angiotension II by radioimmunoassay in women with pregnancy-induced hypertension (n = 54), and compared these values with those obtained in women with normal pregnancy (n = 18) and in non pregnant women (n = 20). Pregnant women had statistically significantly higher plasma angiotensin II [mean (SD): 41.3 (12.6) pg/ml] than non-pregnant women [29.2 (11.3) pg/ml; P less than 0.004]. Angiotensin II concentrations in women with pregnancy-induced hypertension [mean (SD): 31.7 (16.2) pg/ml] were, on average, 25% lower than in normal pregnancy (P less than 0.003) and resembled those obtained in non-pregnant women. The lowest angiotensin II levels were found in women with more severe forms of pregnancy-induced hypertension, such as proteinuric or superimposed pregnancy-induced hypertension. Review of the published studies on angiotensin II and our data suggest that the conflict among studies on angiotensin II levels in pregnancy-induced hypertension is largely due to the heterogeneity of the study populations in the various reports.