Research trends analysis of chronic hepatitis C versus nonalcoholic fatty liver disease: A literature review text‐mining analysis of publications

• Published in: Health science reports Vol. 5; no. 6; pp. e805 - n/a
• Main Authors: Klang, Eyal, Soffer, Shelly, Alper, Lee, Shimon, Orit, Barash, Yiftach, Davidov, Yana, Likhter, Mariya, Cohen‐Ezra, Oranit, Ben Yakov, Gil, Ben‐Ari, Ziv
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.11.2022; John Wiley and Sons Inc; Wiley
• Subjects: Antiviral drugs; chronic hepatitis C; Clinical trials; Data processing; Diabetes; Etiology; Hepatitis; Hepatitis C; Liver cancer; Liver diseases; Meta-analysis; nonalcoholic fatty liver disease; Original Research; PubMed; Regression analysis; Surveillance; text mining; Trends; United States > US; China; nonalcoholic fatty liver disease; text mining; PubMed; chronic hepatitis C
• ISSN: 2398-8835; 2398-8835
• DOI: 10.1002/hsr2.805

Background Hepatits C virus (HCV) rates have lowered due to direct‐acting antiviral treatment. Nonalcoholic steatohepatitis (NASH)/nonalcoholic fatty liver disease (NAFLD) is rising with no available therapy. We employed text‐mining to analyze trends in HCV and NAFLD research from the past two decades. Materials and Methods We queried PubMed for all HCV and NASH/NAFLD entries published between 2000 and 2020. We compared the total number of publications on both etiologies. We performed subanalyses for different terms of interest and for geographic origin. Results Overall, 75,934 HCV‐related entries and 24,987 NASH/NAFLD‐related entries were published during the study period. Up to 2015, there was a linear upward slope in the number of annual HCV publications (154.9 publications/year, p < 0.001). In 2015, the yearly number of HCV publications started showing a downward slope (−242.2 publications/year, p < 0.001). The number of NASH/NAFLD publications showed a continuous upward slope during the study period. The NASH/NAFLD field lacks publications on screening and treatment methods. Conclusion Trends in publications varied between both etiologies. They reflect the success of antiviral treatment for HCV. The growing rates of NAFLD/NASH and the lack of a targeted cure explain the rise in related publications.