Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges

Gastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced stage. Clinical trials show that neoadjuva...

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Published inChronic diseases and translational medicine Vol. 6; no. 3; pp. 147 - 157
Main Authors Zhu, Zhi, Gong, Ying-Bo, Xu, Hui-Mian
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2020
Chinese Medical Association
Wiley
Subjects
Chemotherapy
Gastric cancer
Neoadjuvant therapy
Radiotherapy
Review
Neoadjuvant therapy
Chemotherapy
Radiotherapy
Gastric cancer
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Summary:Gastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced stage. Clinical trials show that neoadjuvant approaches confer a significant survival advantage for resectable locally advanced gastric cancer. The specific advantages of chemoradiotherapy compared with chemotherapy have not been clarified; optimal regimens and cycles, particularly in the preoperative setting, should be studied further; and trials aimed at determining the role of targeted and immunological therapies should be conducted.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2095-882X
2589-0514
2589-0514
DOI:10.1016/j.cdtm.2020.03.004