Effect of PUVA on plasma and skin immunoreactive alpha-melanocyte stimulating hormone concentrations

Plasma alpha-melanocyte stimulating hormone (alpha-MSH) concentrations were measured in patients receiving PUVA therapy as treatment for mycosis fungoides, and PUVA or UVB as treatment for psoriasis. Skin immunoreactive alpha-MSH was also measured in those patients who received PUVA. The mean plasma...

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Bibliographic Details
Published inBritish journal of dermatology (1951) Vol. 117; no. 6; p. 703
Main Authors Spiro, J, Parker, S, Oliver, I, Fraser, C, Marks, J M, Thody, A J
Format Journal Article
LanguageEnglish
Published England 01.12.1987
Subjects
Adult
Aged
alpha-MSH - blood
alpha-MSH - metabolism
Female
Humans
Male
Middle Aged
Mycosis Fungoides - drug therapy
Psoriasis - drug therapy
PUVA Therapy
Skin - metabolism
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Summary:Plasma alpha-melanocyte stimulating hormone (alpha-MSH) concentrations were measured in patients receiving PUVA therapy as treatment for mycosis fungoides, and PUVA or UVB as treatment for psoriasis. Skin immunoreactive alpha-MSH was also measured in those patients who received PUVA. The mean plasma and skin alpha-MSH concentrations after 2-3 weeks of PUVA were not significantly different from pre-treatment values and showed no relationship either to skin type or to the degree of tanning that occurred in response to PUVA. Plasma alpha-MSH concentrations were also unchanged after UVB. There was also no short term change in plasma alpha-MSH concentrations in patients after receiving their first treatment with PUVA. It would appear that circulating and skin alpha-MSH levels are unaffected by UV and show no causal relationship to PUVA induced pigmentation.
ISSN:0007-0963
DOI:10.1111/j.1365-2133.1987.tb07349.x