Synergistic effects of ethanol and hyperthermia on carotid artery vasoconstriction

• Published in: Clinical physiology and functional imaging Vol. 27; no. 3; pp. 185 - 190
• Main Authors: Mustafa, S., Thulesius, O., Elgazzar, A. H., Ismael, H. N.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2007; Blackwell Science
• Subjects: alcohol; Animals; Biological and medical sciences; Body Temperature; Brain Ischemia - diagnostic imaging; Brain Ischemia - etiology; Brain Ischemia - physiopathology; Carotid Arteries - drug effects; Carotid Arteries - physiopathology; carotid artery; Dose-Response Relationship, Drug; Ethanol - pharmacology; Fever - complications; Fever - diagnostic imaging; Fever - physiopathology; Fundamental and applied biological sciences. Psychology; Heat Stroke - etiology; hyperthermia; Male; Rabbits; Radionuclide Imaging; stroke; Stroke - diagnostic imaging; Stroke - etiology; Stroke - physiopathology; technetium-99m-hexamethyl-propyleneamineoxime; Vasoconstriction; Vertebrates: anatomy and physiology, studies on body, several organs or systems; alcohol; Nervous system diseases; Stroke; technetium-99m-hexamethyl-propyleneamineoxime; Ethanol; Vasoconstriction; Cardiovascular disease; Technetium; Artery; Cerebral disorder; Vascular disease; Vasomotricity; Vertebrata; Mammalia; Blood vessel; Carotid; Central nervous system disease; Circulatory system; Hyperthermia; carotid artery; Cerebrovascular disease
• ISSN: 1475-0961; 1475-097X
• DOI: 10.1111/j.1475-097X.2007.00733.x

Summary Background:  Heatstroke is a serious condition and clinical studies indicate that vascular stroke increases with excessive consumption of alcohol (ethanol). It was our objective to test the influence of ethanol on cerebral perfusion at normal and higher temperatures. Methods:  Recording of isometric tension in rabbit carotid artery strips in organ baths with different concentrations of ethanol at 37°C and during hyperthermia (39–43°C) and scintigraphic cerebral imaging of a radioactive isotope in the control situation and during hyperthermia. Results:  Stepwise heating induced reproducible reversible graded contraction, proportional to temperature. At high concentrations (toxic levels), ethanol induced an increase in tension and heating potentiated these responses. Extracellular Mg2+ potentiated both heat‐induced contraction and ethanol‐induced contraction while extracellular Ca2+ had no effect on these responses. During hyperthermia and ethanol scintigraphic isotope uptake was reduced in cortical and cerebellar regions. Conclusions:  Carotid artery vasomotor tone is temperature dependent and heating induces vasoconstriction. Alcohol (ethanol) at 37°C elicited carotid artery contraction at high concentrations (toxic levels) but at any concentration during elevated temperature (39–43°C). Ethanol potentiated the effect of hyperthermia‐induced vasoconstriction and reduced cerebral perfusion as shown by radionuclide imaging. The synergistic effect of ethanol and hyperthermia may induce heat stroke and brain damage.