Incidence of complications and mortality in a type 2 diabetes patient cohort study followed up from diagnosis in a primary healthcare centre

• Published in: International journal of clinical practice (Esher) Vol. 65; no. 3; pp. 299 - 307
• Main Authors: Mata-Cases, M., De Prado-Lacueva, C., Salido-Valencia, V., Fernández-Bertolín, E., Casermeiro-Cortés, J., García-Durán, M., Jabalera-López, S., Fernández-Sanmartín, M. I.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2011; Wiley-Blackwell; Hindawi Limited
• Subjects: Aged; Biological and medical sciences; Cholesterol, HDL - metabolism; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - mortality; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - blood; Diabetic Angiopathies - complications; Diabetic Angiopathies - mortality; Diabetic Nephropathies - complications; Diabetic Nephropathies - mortality; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epidemiologic Methods; Epidemiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; General aspects; Glycated Hemoglobin A - metabolism; Humans; Male; Medical diagnosis; Medical sciences; Middle Aged; Morbidity; Mortality; Public health. Hygiene; Public health. Hygiene-occupational medicine; Spain - epidemiology; Endocrinopathy; Type 2 diabetes; Primary health care; Mortality; Patient follow-up; Metabolic diseases; Epidemiology; Incidence; Medicine; Cohort study; Complication; Diagnosis; Public health
• ISSN: 1368-5031; 1742-1241
• DOI: 10.1111/j.1742-1241.2010.02503.x

Summary Aims:  To determine the microvascular and macrovascular complications and mortality incidence rates and to identify the related factors in patients recently diagnosed with type 2 diabetes between 1991 and 2000 and followed until 2006. Methods:  Retrospective longitudinal study in a primary healthcare center. Patients without any measure of glycaemia in the 3 years previous to diabetes diagnosis were excluded. Annual incidence rates for microvascular and macrovascular complications and mortality were estimated. Analysis of KaplanMeier survival curves and Cox proportional risk models by gender were done. Results:  Of 469 patients [mean age: 60.4 (SD 10.7) years, 53.9% women], 80 died principally of tumoral (38.7%) and cardiovascular (30%) causes. The mean follow‐up period was 8.81 years. (SD 3.21). The complication rates per 1000 patients/year (95% CI) were: microvascular complications 29.11 (22.97–36.38), macrovascular complications 24.10 (19.05–30.08) and mortality 19.23 (15.25–23.93), all of those being significantly greater in males except for cerebrovascular disease. Complications and mortality were associated with age, HbA1c, HDL‐cholesterol, blood pressure and smoking with a different significance for each gender. HbA1c was related to microvascular complications in both sexes and to macrovascular complications only in women. Conclusion:  The annual rates for death and complications in a Mediterranean type 2 diabetic patient cohort followed from diagnosis were lower than those published in Anglo‐Saxon countries. Males showed higher death and complication rates except in terms of cerebrovascular disease. Predictors of complication and death were different depending on gender. In terms of mortality, unlike in other studies, only one‐third of the deaths were for cardiovascular causes.