Oleanolic acid induces autophagic death in human gastric cancer cells in vitro and in vivo

• Published in: Cell biology international Vol. 40; no. 7; pp. 770 - 778
• Main Authors: Nie, Hao, Wang, Yu, Qin, Yong, Gong, Xing-Guo
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2016; Wiley Subscription Services, Inc
• Subjects: Animals; Apoptosis - drug effects; Apoptosis Regulatory Proteins - metabolism; autophagic death; Autophagy; Autophagy - drug effects; Beclin-1 - genetics; Cell Line, Tumor; Female; Gastric cancer; Humans; in vivo; MAP Kinase Signaling System - drug effects; Mice; Mice, Inbred BALB C; Mice, Nude; mTOR; oleanolic acid; Oleanolic Acid - pharmacology; Proto-Oncogene Proteins c-akt - metabolism; Random Allocation; RNA, Small Interfering - administration & dosage; RNA, Small Interfering - genetics; Signal Transduction - drug effects; Stomach Neoplasms - drug therapy; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; TOR Serine-Threonine Kinases - metabolism; Transfection; Xenograft Model Antitumor Assays; mTOR; autophagic death; in vivo; gastric cancer; oleanolic acid

Oleanolic acid (OA), a plant‐derived pentacyclic terpenoid, is known to have hepatoprotective effects. In this study, we found that OA induced autophagic cell death in multiple human gastric cancer cell lines. Moreover, OA‐induced autophagy was shown for the first time in human gastric cancer cells,...