Acute tolerance to diazepam induced by benzodiazepines

It was observed that the effectiveness of diazepam in causing sleep, as defined by the loss of righting reflex, was significantly decreased after a single exposure to either diazepam or lorazepam. RO 15-1788, a benzodiazepine antagonist, in contrast did not induce tolerance to diazepam. The mechanis...

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Bibliographic Details
Published inClinical and experimental pharmacology & physiology Vol. 13; no. 1; p. 1
Main Authors Wong, P T, Yoong, Y L, Gwee, M C
Format Journal Article
LanguageEnglish
Published Australia 01.01.1986
Subjects
Animals
Benzodiazepines - pharmacology
Benzodiazepinones - pharmacology
Diazepam - pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Drug Tolerance
Flumazenil
Lorazepam - pharmacology
Male
Mice
Sleep - drug effects
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Summary:It was observed that the effectiveness of diazepam in causing sleep, as defined by the loss of righting reflex, was significantly decreased after a single exposure to either diazepam or lorazepam. RO 15-1788, a benzodiazepine antagonist, in contrast did not induce tolerance to diazepam. The mechanism for this acute tolerance is unclear. The rapidity in its development may exclude metabolic tolerance while alterations in brain sensitivity to diazepam remain a possibility.
ISSN:0305-1870
DOI:10.1111/j.1440-1681.1986.tb00309.x