Magnetic resonance imaging evaluation of the effects of ageing on grey-white ratio in the human brain
A previous neuropathological report noted a non-linear pattern of change in cerebral grey-white matter ratio during ageing. In that report, grey-white ratio decreased from age 20 to age 50, then increased in elderly subjects. The objective of the current study was to attempt to replicate this patter...
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Published in | Neuropathology and applied neurobiology Vol. 20; no. 3; p. 290 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.06.1994
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Subjects | |
Online Access | Get more information |
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Summary: | A previous neuropathological report noted a non-linear pattern of change in cerebral grey-white matter ratio during ageing. In that report, grey-white ratio decreased from age 20 to age 50, then increased in elderly subjects. The objective of the current study was to attempt to replicate this pattern of age-related change in the grey-white ratio in living human subjects using quantitative magnetic resonance imaging segmentation analysis. We measured the grey-white ratio in 78 subjects between the ages of 19 and 77 years, using a computer segmentation algorithm with magnetic resonance images. In agreement with the previous neuropathological report, the current in vivo magnetic resonance study found that the grey-white ratio declined from age 20 to age 50, then increased in elderly subjects. |
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ISSN: | 0305-1846 |
DOI: | 10.1111/j.1365-2990.1994.tb00971.x |