Is splenectomy more dangerous for massive spleens?

• Published in: The American journal of surgery Vol. 175; no. 2; pp. 102 - 107
• Main Authors: McAneny, David, LaMorte, Wayne W., Scott, Thayer E., Weintraub, Lewis R., Beazley, Robert M.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.1998; Elsevier; Elsevier Limited
• Subjects: Age; Age Factors; Biological and medical sciences; Blood diseases; Comorbidity; Complications; Death; Female; Health hazards; Hematologic Diseases - complications; Hematologic Diseases - surgery; Hematological diseases; Humans; Liver, biliary tract, pancreas, portal circulation, spleen; Logistic Models; Male; Medical sciences; Middle Aged; Morbidity; Mortality; Multivariate Analysis; Postoperative; Risk Factors; Splenectomy; Splenectomy - adverse effects; Splenomegaly - surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Treatment Outcome; Human; Splenectomy; Treatment; Surgery; Mortality; Size; Complication; Hemopathy; Age; Morbidity
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/S0002-9610(97)00264-X

Reports vary about whether risks are greater for removal of massive (≥1500 g) spleens than for smaller (<1500 g) spleens. We sought to determine the hazards of splenectomy. methods: We reviewed 223 consecutive adults with elective splenectomies for hematologic diseases. Morbidity and mortality rates were combined with published data to create a meta-analysis. Patients with massive spleens are more likely to have postoperative complications (relative risk [RR] 2.1, 95% confidence interval [Cl] 1.3 to 3.4; P = 0.003) and death (RR 4.7, 95% Cl, 1.5 to 15.1; P = 0.01). However, when the investigation is restricted to comparable diagnoses, patients with massive spleens do not differ from those with smaller spleens regarding complications (RR 1.4, 95% Cl, 0.8 to 2.7; P = 0.3) or mortality (RR 2.1, 95% Cl, 0.5 to 9.7; P = 0.4). These observations are confirmed by metaanalysis. Furthermore, multivariate analysis indicts age as a critical risk of complications and death. Increased age and underlying illness are the predominant factors associated with morbidity and mortality following splenectomy for hematologic disease. Adjusting for age and diagnosis, spleen size is not a hazard.