Lung Transplantation for Severe Antineutrophilic Cytoplasmic Antibody-Associated Vasculitis

• Published in: Transplantation proceedings Vol. 42; no. 7; pp. 2707 - 2710
• Main Authors: Weinkauf, J, Puttagunta, L, Stewart, K, Humar, A, Homik, J, Caldwell, S, Fenton, M, Nador, R, Lien, Dale
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.09.2010; Elsevier
• Subjects: Adolescent; Antibodies, Antineutrophil Cytoplasmic - blood; Antibodies, Antinuclear - immunology; Biological and medical sciences; Cyclophosphamide; Cytoplasm - immunology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Glomerulonephritis - etiology; Hemoptysis; Hemorrhage - etiology; Humans; Lung Transplantation - immunology; Lung Transplantation - physiology; Male; Medical sciences; Plasmapheresis; Renal Dialysis - methods; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Treatment Outcome; Vasculitis - immunology; Vasculitis - surgery; Antibody; Lung; Cardiovascular disease; Transplantation; Homotransplantation; Respiratory system; Vascular disease; Medicine; Treatment; Vasculitis; Surgery; Graft; Severe; Cytoplasm
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2010.04.053

Abstract Antineutrophil cytoplasmic antibody–associated vasculitis is a life-threatening disorder for which medical therapy has greatly improved survival. However, there is still significant mortality associated with antineutrophil cytoplasmic antibody–associated vasculitis. Little data exists on the utility of lung transplantation for patients, especially with an acute and severe form of this disease. Herein, we report successful lung transplantation for a patient with life-threatening pulmonary hemorrhage and respiratory failure as a consequence of this pulmonary renal syndrome.