Prognostic Value of Ambulatory Blood-Pressure Recordings in Patients with Treated Hypertension

• Published in: The New England journal of medicine Vol. 348; no. 24; pp. 2407 - 2415
• Main Authors: Clement, Denis L, De Buyzere, Marc L, De Bacquer, Dirk A, de Leeuw, Peter W, Duprez, Daniel A, Fagard, Robert H, Gheeraert, Peter J, Missault, Luc H, Braun, Jacob J, Six, Roland O, Van Der Niepen, Patricia, O'Brien, Eoin
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 12.06.2003
• Subjects: Antihypertensive Agents - therapeutic use; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiology. Vascular system; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - mortality; Cardiovascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Female; Follow-Up Studies; Humans; Hypertension; Hypertension - complications; Hypertension - diagnosis; Hypertension - drug therapy; Hypertension - mortality; Incidence; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Office Visits; Prognosis; Proportional Hazards Models; Risk Factors; Studies; Human; Hypertension; Measurement; Chemotherapy; Treatment; Diastole; Follow up study; Cardiovascular disease; Arterial pressure; Ambulatory; Systole; Predictive factor
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa022273

In this prospective, multicenter study of treated hypertensive patients, ambulatory blood-pressure readings predicted the risk of cardiovascular events during five years of follow-up, even after adjustment for office-based blood-pressure measurements and other cardiovascular risk factors. In hypertensive patients the readings predicted the risk of events. Several prospective clinical studies, as well as population-based studies, have indicated that the incidence of cardiovascular events is predicted by blood pressure as measured conventionally or with ambulatory methods, even after adjustment for a number of established risk factors. 1 – 11 In some of these studies, ambulatory measurements of blood pressure predicted cardiovascular events even after adjustment for conventional blood-pressure measurements. 1 , 3 , 5 , 7 , 9 , 12 However, in most of these studies, the majority of data on ambulatory blood pressure, which were used to predict end points, were recorded in initially untreated subjects or during a placebo run-in phase; in most . . .