Gene Expression Profiles Associated with Radio-Responsiveness in Locally Advanced Rectal Cancer

• Published in: Biology (Basel, Switzerland) Vol. 10; no. 6; p. 500
• Main Authors: Lee, Jeeyong, Kwon, Junhye, Kim, DaYeon, Park, Misun, Kim, KwangSeok, Bae, InHwa, Kim, Hyunkyung, Kong, JoonSeog, Kim, Younjoo, Shin, UiSup, Kim, EunJu
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 03.06.2021; MDPI
• Subjects: bio-marker; Biomarkers; Biopsy; Cancer; Cancer therapies; Cathepsin E; Chemotherapy; Colorectal cancer; DNA methylation; DNA repair; Drug dosages; Endoscopy; Epidermal growth factor; Gene expression; Immune system; Medical prognosis; Medical research; Organoids; Patients; Precision medicine; Radiation therapy; radio-responsiveness; rectal cancer; Rectum; Surgery; Tumors; United States > US; Germany

LARC patients were sorted according to their radio-responsiveness and patient-derived organoids were established from the respective cancer tissues. Expression profiles for each group were obtained using RNA-seq. Biological and bioinformatic analysis approaches were used in deciphering genes and pat...