Feasibility and efficacy of endoscopic ultrasound-guided iodine-125 seed implantation in inoperable ampullary carcinoma: initial clinical experience

Purpose The objectives of the present study were to evaluate the feasibility, safety, and efficacy of endoscopic ultrasound (EUS)-guided iodine-125 (125I) seed implantation in ampullary carcinoma (AC). Material and methods From January 2011 to June 2020, 13 patients were selected for this retrospect...

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Published inJournal of contemporary brachytherapy Vol. 14; no. 3; pp. 233 - 240
Main Authors Cui, Tingting, Han, Lianqiang, Xiao, Nianjun, Liu, Fang, Li, Wen
Format Journal Article
LanguageEnglish
Published Poznan Termedia Publishing House 01.01.2022
Subjects
adenocarcinoma
ampullary
brachytherapy
Confidence intervals
endoscopic ultrasound
Endoscopy
Feasibility studies
Implantation
Iodine
Iodine 125
Iodine isotopes
Original Paper
Survival
Target detection
Tumors
Ultrasonic imaging
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Summary:Purpose The objectives of the present study were to evaluate the feasibility, safety, and efficacy of endoscopic ultrasound (EUS)-guided iodine-125 (125I) seed implantation in ampullary carcinoma (AC). Material and methods From January 2011 to June 2020, 13 patients were selected for this retrospective study. Thirteen tumors (27.46 ±12.07 mm) were treated with EUS-guided 125I seed implantation in 29 sessions. We evaluated the therapeutic efficacy, adverse effects, and overall survival (OS) time. Results Complete response (CR) was observed in one tumor in 6 months. Partial response (PR) was detected in two target tumors in 3 months, seven in 6 months, seven in 9 months, and six in 12 months. Good periods of survival were observed. The median OS was 35 months, 95% confidence interval (95% CI) was 8.97 to 61.03 months. The 1-, 2-, and 5-year OS rates were 100%, 67.5%, and 11.3%, respectively. There were no procedure-related deaths or serious adverse events. Transient abdominal pain (5 cases, 17.2%), abdominal distension and loss of appetite (3 cases, 10.3%), and seed migration (1 case, 3.4%) were observed, respectively. Conclusions In selected patients with inoperable AC, EUS-guided 125I seed implantation is feasible and safe with favorable local control efficacy and OS.
Bibliography:ObjectType-Article-1
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Tingting Cui and Lianqiang Han contribute equally as the joint first authors.
ISSN:1689-832X
2081-2841
DOI:10.5114/jcb.2022.116121