Hemodynamic recovery after hypovolemic shock with lactated Ringer's and keratin resuscitation fluid (KRF), a novel colloid

• Published in: Artificial cells, nanomedicine, and biotechnology Vol. 41; no. 5; pp. 293 - 303
• Main Authors: Nunez, Fiesky A., Callahan, Michael F., Trach, Simon, Burnett, Luke R., Kislukhin, Victor, Smith, Thomas L., Van Dyke, Mark
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.10.2013; Taylor & Francis
• Subjects: Animals; Carotid Arteries - surgery; Colloids - administration & dosage; Disease Models, Animal; Hemodynamics; Humans; Hyperoncotic; hyperviscous colloid; hypovolemia; Hypovolemia - surgery; Hypovolemia - therapy; Isotonic Solutions - administration & dosage; keratin biomaterials; Keratins - administration & dosage; keratose; low volume resuscitation; Male; permissive hypotension; Rats; Rats, Sprague-Dawley; Recovery of Function; resuscitation; Resuscitation - methods; United States; United States
• ISSN: 2169-1401; 2169-141X
• DOI: 10.3109/21691401.2012.747533

Abstract Death after severe hemorrhage remains an important cause of mortality in people under 50 years of age. Keratin resuscitation fluid (KRF) is a novel resuscitation solution made from keratin protein that may restore cardiovascular stability. This postulate was tested in rats that were exsanguinated to 40% of their blood volume. Test groups received either low or high volume resuscitation with either KRF or lactated Ringer's solution. KRF low volume was more effective than LR in recovering cardiac function, blood pressure and blood chemistry. Furthermore, in contrast to LR-treated rats, KRF-treated rats exhibited vital signs that resembled normal controls at 1-week.