The tumor-draining lymph node as a reservoir for systemic immune surveillance

Early in solid tumor development, antigens are presented in tumor-draining lymph nodes (tdLNs), a process that is necessary to set up immune surveillance. Recent evidence indicates that tdLNs fuel systemic tumor-specific T cell responses which may halt cancer progression and facilitate future respon...

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Bibliographic Details
Published inTrends in cancer Vol. 10; no. 1; p. 28
Main Authors Delclaux, Ines, Ventre, Katherine S, Jones, Dennis, Lund, Amanda W
Format Journal Article
LanguageEnglish
Published United States 01.01.2024
Subjects
Humans
Immunotherapy
Lymph Nodes
Lymphatic Metastasis - pathology
T-Lymphocytes
metastasis
lymph node
immune surveillance
immunotherapy
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Summary:Early in solid tumor development, antigens are presented in tumor-draining lymph nodes (tdLNs), a process that is necessary to set up immune surveillance. Recent evidence indicates that tdLNs fuel systemic tumor-specific T cell responses which may halt cancer progression and facilitate future responses to immunotherapy. These protective responses, however, are subject to progressive dysfunction exacerbated by lymph node (LN) metastasis. We discuss emerging preclinical and clinical literature indicating that the tdLN is a crucial reservoir for systemic immunity that can potentiate immune surveillance. We also discuss the impact of LN metastasis and argue that a better understanding of the relationship between LN metastasis and systemic immunity will be necessary to direct regional disease management in the era of immunotherapy.
ISSN:2405-8025
DOI:10.1016/j.trecan.2023.09.006