Interleukin-15: its role in microbial infections

Interleukin-15 (IL-15) is a pleiotropic cytokine which regulates the proliferation, survival and the secretory activities of many distinct cell types in the body. This cytokine is produced by macrophages and many other cell types in response to infectious agents; it controls growth and differentiati...

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Published inThe journal of venomous animals and toxins including tropical diseases Vol. 13; no. 3; pp. 562 - 575
Main Authors Bannwart, C.F.(São Paulo State University Institute of Biosciences Department of Microbiology and Immunology), Nakaira, E.T.(São Paulo State University Institute of Biosciences Department of Microbiology and Immunology), Sartori, A.(São Paulo State University Institute of Biosciences Department of Microbiology and Immunology), Peraçoli, M.T.S.(São Paulo State University Institute of Biosciences Department of Microbiology and Immunology)
Format Journal Article
LanguageEnglish
Portuguese
Published Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP 2007
Centro de Estudos de Venenos e Animais Peçonhentos
SciELO
Subjects
innate immunity
Interleukin-15
microbial infections
TOXICOLOGY
TROPICAL MEDICINE
innate immunity
Interleukin-15
microbial infections
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Summary:Interleukin-15 (IL-15) is a pleiotropic cytokine which regulates the proliferation, survival and the secretory activities of many distinct cell types in the body. This cytokine is produced by macrophages and many other cell types in response to infectious agents; it controls growth and differentiation of T and B lymphocytes, activation of Natural Killer (NK) and phagocytic cells, and contributes to the homeostasis of the immune system. The present review focuses on the biological and modulatory effects of IL-15 in microbial infections and shows that this cytokine may play a role in the host defense against infections by inducing activation of effector cells from both innate and adaptive immune system.
Bibliography:10.1590/S1678-91992007000300002
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000300002
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ISSN:1678-9199
1678-9199
DOI:10.1590/S1678-91992007000300002