Synthesis and antimicrobial activity of some new 1,3,4-thiadiazole and 1,2,4-triazole compounds having a D,L-methionine moiety

• Published in: Molecules (Basel, Switzerland) Vol. 12; no. 1; pp. 103 - 113
• Main Authors: Pintilie, Otilia, Profire, Lenuta, Sunel, Valeriu, Popa, Marcel, Pui, Aurel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.01.2007; MDPI
• Subjects: 4-Thiadiazole; 4-triazole; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antimicrobial activity; Antimicrobial agents; Bacillus anthracis - drug effects; Bacillus cereus - drug effects; Chemistry; E coli; Investigations; L-methionine; Methionine - chemistry; Microbial Sensitivity Tests; Pharmacy; Sarcina - drug effects; Spectrophotometry, Infrared; Staphylococcus aureus - drug effects; Structure-Activity Relationship; Thiadiazoles - chemical synthesis; Thiadiazoles - chemistry; Thiadiazoles - pharmacology; thiosemicarbazide; Triazoles - chemical synthesis; Triazoles - chemistry; Triazoles - pharmacology; Romania
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/12010103

New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively. The potential antimicrobial effects of the synthesized compounds were investigated using the Staphylococcus aureus ATCC 25923, Bacillus antracis ATCC 8705, Bacillus cereus ATCC 10987, Sarcina lutea ATCC 9341 and Escherichia coli ATCC 25922 strains. The newly synthesized compounds exhibited promising activities against Bacillus antracis and Bacillus cereus.