Psychiatric Aspects of Acute Porphyria: a Comprehensive Review

• Published in: Current psychiatry reports Vol. 20; no. 1; p. 5
• Main Authors: Duque-Serrano, Laura, Patarroyo-Rodriguez, Liliana, Gotlib, Dorothy, Molano-Eslava, Juan C.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2018; Springer Nature B.V
• Subjects: Analgesics - therapeutic use; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Comorbidity; Complex Medical-Psychiatric Issues (MB Riba; Humans; Liver diseases; Medical diagnosis; Medicine; Medicine & Public Health; Mental Disorders - etiology; Mental Disorders - physiopathology; Mental Disorders - therapy; Personality; Porphyria, Acute Intermittent - complications; Porphyria, Acute Intermittent - psychology; Psychiatry; Psychopathology; Section Editor; Topical Collection on Complex Medical-Psychiatric Issues; Psychosis; Consult-liaison psychiatry; Mental disorders; Acute intermittent porphyria; Acute porphyria; Personality traits
• ISSN: 1523-3812; 1535-1645
• DOI: 10.1007/s11920-018-0867-1

Purpose of Review The aim of this paper is to review psychiatric manifestations, comorbidities, and psychopharmacological management in individuals with acute porphyria (AP). Recent Findings Recent literature begins to clarify associations between AP, schizophrenia, bipolar disorder, and other psychopathology. Summary Broad psychiatric symptoms have been associated to acute porphyria (AP) and correspond to a spectrum of heterogeneous manifestations such as anxiety, affective alterations, behavioral changes, personality, and psychotic symptoms. These symptoms may be difficult to identify as being related to porphyria since symptoms may arise at any time during the disease process. In addition, these patients may present psychiatric conditions secondary to the disease, such as adjustment disorder and substance use disorders. Timely diagnosis and appropriate treatment of psychiatric manifestations positively impact the course of the disease.