Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET

• Published in: Nuclear medicine and molecular imaging Vol. 53; no. 5; pp. 334 - 339
• Main Authors: Jeong, Jieun, Jeong, Young Jin, Park, Kyung Won, Kang, Do-Young
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019; Springer Nature B.V; 대한핵의학회
• Subjects: Adults; Cardiology; Computed tomography; Emission analysis; Fluorine isotopes; Imaging; Medicine; Medicine & Public Health; Normalizing; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; Positron emission; Radioisotopes; Radiology; Tomography; 방사선과학; SUVR; Alzheimer’s disease; Healthy; F-18 florbetaben
• ISSN: 1869-3474; 1869-3482
• DOI: 10.1007/s13139-019-00609-7

Purpose To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB). Methods We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively healthy adults (age range, 50–70 years) using automated quantification. The standardized uptake value ratios (SUVRs) of F-18 FBB were calculated for predefined regions by normalizing the regional count with cerebellar cortex. Results The distribution of amyloid beta for each brain region revealed no age-related trends ( p  > 0.05). From all subjects, mean SUVR of amyloid deposit was 1.30 ± 0.18. The right parietal lobe showed the highest SUVR value (1.46 ± 0.23), whereas the right frontal lobe and left precuneus showed the lowest SUVR (1.23 ± 0.25). Conclusions We provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer’s disease.