Connecting the Dots: Exploring the Interplay Between Preeclampsia and Peripartum Cardiomyopathy

• Published in: Journal of pregnancy Vol. 2024; no. 1; p. 7713590
• Main Authors: Gumilar, Khanisyah Erza, Rauf, Khairunnisa Binti Abd, Akbar, Muhammad Ilham Aldika, Imanadha, Nareswari Cininta, Atmojo, Susetyo, Putri, Alisia Yuana, Dachlan, Erry Gumilar, Dekker, Gus
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi Limited 25.06.2024; Wiley
• Subjects: Blood pressure; Blood vessels; Cardiology; Cardiomyopathies - etiology; Cardiomyopathies - genetics; Cardiomyopathies - physiopathology; Cardiomyopathy; Cesarean section; Childbirth & labor; Comorbidity; Diagnosis; Diuretics; Edema; Endothelium, Vascular - physiopathology; Epidural; Female; Genetic Predisposition to Disease; Health aspects; Heart diseases; Heart failure; Humans; Hypertension; Immunology; Kidneys; Kinases; Maternal mortality; Patients; Peripartum Period; Pre-eclampsia; Pre-Eclampsia - genetics; Pre-Eclampsia - physiopathology; Preeclampsia; Pregnancy; Pregnancy Complications, Cardiovascular - genetics; Pregnancy Complications, Cardiovascular - physiopathology; Pregnant women; Prenatal care; Review; Risk factors; Womens health; Indonesia; genetic; preeclampsia; endothelial dysfunctions; peripartum cardiomyopathy; inflammatory
• ISSN: 2090-2727; 2090-2735; 2090-2735
• DOI: 10.1155/2024/7713590

Preeclampsia and peripartum cardiomyopathy (PPCM) are significant obstetric problems that can arise during or after pregnancy. Both are known to be causes of maternal mortality and morbidity. Several recent studies have suggested a link between preeclampsia and the pathophysiology of PPCM. However, the common thread that connects the two has yet to be thoroughly and fully articulated. Here, we investigate the complex dynamics of preeclampsia and PPCM in this review. Our analysis focuses mainly on inflammatory and immunological responses, endothelial dysfunction as a shared pathway, and potential genetic predisposition to both diseases. To begin, we will look at how excessive inflammatory and immunological responses can lead to clinical symptoms of both illnesses, emphasizing the role of proinflammatory cytokines and immune cells in modifying vascular and tissue responses. Second, we consider endothelial dysfunction to be a crucial point at which endothelial damage and activation contribute to pathogenesis through increased vascular permeability, vascular dysfunction, and thrombus formation. Finally, we examine recent information suggesting genetic predispositions to preeclampsia and PPCM, such as genetic variants in genes involved in the management of blood pressure, the inflammatory response, and heart structural integrity. With this synergistic study, we seek to encourage more research and creative therapy solutions by emphasizing the need for an interdisciplinary approach to understanding and managing the connection between preeclampsia and PPCM.