Plasma B-type natriuretic peptide (BNP) in acute Puumala hantavirus infection

• Published in: Annals of medicine (Helsinki) Vol. 46; no. 1; p. 38
• Main Authors: Rajaniemi, Saara-Mari, Hautala, Nina, Sironen, Tarja, Vainio, Olli, Vapalahti, Olli, Vaheri, Antti, Vuolteenaho, Olli, Ruskoaho, Heikki, Kauma, Heikki, Hautala, Timo
• Format: Journal Article
• Language: English
• Published: England 01.02.2014
• Subjects: Acute Disease; Adult; Eye - physiopathology; Female; Hemorrhagic Fever with Renal Syndrome - blood; Hemorrhagic Fever with Renal Syndrome - physiopathology; Hemorrhagic Fever with Renal Syndrome - virology; Humans; Kidney Function Tests; Male; Middle Aged; Natriuretic Peptide, Brain - adverse effects; Natriuretic Peptide, Brain - blood; Prospective Studies; Protein Precursors - adverse effects; Protein Precursors - blood; Puumala virus - pathogenicity; Water-Electrolyte Balance
• ISSN: 1365-2060
• DOI: 10.3109/07853890.2013.862960

Nephropathia epidemica (NE) is a haemorrhagic fever with renal syndrome (HFRS) caused by Puumala hantavirus (PUUV). Acute infection causes transient kidney injury, permeability disorder, and fluid retention, for example. B-type natriuretic peptide (BNP) and N-terminal peptide (NT-proBNP) during NE were investigated; disease severity and development of clinical symptoms were considered. Mean concentrations were 80.2 pg/mL and 55.2 pg/mL for BNP, and 2362.5 pg/mL and 1057.0 pg/mL for NT-proBNP in males and females, respectively. Hospitalization was 6.3 versus 5.2 days (P = 0.01) and 5.9 versus 4.4 days (P = 0.01) for patients with elevated BNP (> 100 pg/mL) or NT-proBNP (> 300 pg/mL), respectively, compared to those with normal peptide concentrations. Weight change during hospitalization was -2.8 or -0.3 kg (P <0.05) in patients with elevated or normal BNP, respectively. Heart rate (r = -0.46, P = 0.001 and r = -0.37, P = 0.01), creatinine clearance (r = -0.46, P = 0.001 and r = -0.56, P = 0.000), blood haemoglobin concentration (r = -0.55, P = 0.000 and r = -0.52, P = 0.000), and C-reactive protein (r = -0.47, P = 0.001 and r = -0.36, P = 0.01) measured when the peptide samples were collected correlated with BNP and NT-proBNP, respectively. In addition, anterior chamber depth of eye and plasma BNP (r = -0.39, P < 0.05) displayed a correlation. BNP and NT-proBNP levels are associated with severity of several clinical features of acute NE.