Trypsin Activity in Secretagogue-induced Murine Pancreatitis Is Solely Elicited by Cathepsin B and Does Not Mediate Key Pathologic Responses

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Bibliographic Details
Published inGastroenterology (New York, N.Y. 1943) Vol. 164; no. 4; pp. 684 - 687.e4
Main Authors Geisz, Andrea, Tran, Thanh, Orekhova, Anna, Sahin-Tóth, Miklós
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2023
Subjects
Animals
Cathepsin B
Ceruletide - adverse effects
Mice
Pancreas - pathology
Pancreatitis - chemically induced
Pancreatitis - pathology
Secretagogues - adverse effects
Trypsin
Trypsinogen
CTSB
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content type line 63
ObjectType-Correspondence-2
Author contributions: AG and MST conceived and directed the study. AG and MST designed the experiments. AG, TT, and AO performed the experiments. AG, TT, AO, and MST analyzed the data. AG and MST wrote the manuscript, AG prepared the figures. All authors read and approved the manuscript.
ISSN:0016-5085
1528-0012
DOI:10.1053/j.gastro.2023.01.004