A Unique SARS-CoV-2 Spike Protein P681H Variant Detected in Israel

The routine detection, surveillance, and reporting of novel SARS-CoV-2 variants is crucial, as these threaten to hinder global vaccination efforts. Herein we report a novel local variant with a non-synonymous mutation in the spike (S) protein P681H. This local Israeli variant was not associated with...

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Published inVaccines (Basel) Vol. 9; no. 6; p. 616
Main Authors Zuckerman, Neta, Fleishon, Shay, Bucris, Efrat, Bar-Ilan, Dana, Linial, Michal, Bar-Or, Itay, Indenbaum, Victoria, Weil, Merav, Lustig, Yaniv, Mendelson, Ella, Mandelboim, Michal, Mor, Orna
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 08.06.2021
MDPI
Subjects
Bioinformatics
Brief Report
Coronaviruses
Covid-19
Genomes
Infections
Mutation
Phylogenetics
Proteins
Quality control
SARS-CoV-2
sequencing
Severe acute respiratory syndrome coronavirus 2
Spike protein
Surveillance
Testing laboratories
Vaccination
variant of concern
virus neutralization
Viruses
United Kingdom > UK
Israel
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Summary:The routine detection, surveillance, and reporting of novel SARS-CoV-2 variants is crucial, as these threaten to hinder global vaccination efforts. Herein we report a novel local variant with a non-synonymous mutation in the spike (S) protein P681H. This local Israeli variant was not associated with a higher infection rate or higher prevalence. Furthermore, the local variant was successfully neutralized by sera from fully vaccinated individuals at a comparable level to the B.1.1.7 variant and an Israel wild-type strain. While it is not a variant of concern, routine monitoring by sequencing is still required.
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These authors contributed equally to the manuscript.
Israel National Consortium for SARS-CoV-2 sequencing: Neta Zuckerman, Efrat Dahan Bucris, Michal Mandelboim, Dana Bar-Ilan, Oran Erster, Tzvia Mann, Omer Murik, David A. Zeevi, Assaf Rokney, Joseph Jaffe, Eva Nachum, Maya Davidovich Cohen, Ephraim Fass, Gal Zizelski Valenci, Mor Rubinstein, Efrat Rorman, Israel Nissan, Efrat Glick-Saar, Omri Nayshool, Gideon Rechavi, Ella Mendelson, Orna Mor.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines9060616