Synthesis and characterization of novel polyurethane cationomers with dipeptide sequences and alkylammonium groups
A synthetic approach to polyurethane cationomers containing S-pyroglutamyl-S-glutamic acid dipeptide (S-PyGlu-S-Glu) and alkylammonium groups is presented. Two segmented polycations, based on polycaprolactone diol, isophorone diisocyanate and dipeptide together with N-methyldiethanolamine, subsequen...
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Published in | Journal of biomaterials science. Polymer ed. Vol. 15; no. 6; pp. 781 - 795 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Taylor & Francis Group
01.01.2004
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Subjects | |
Online Access | Get full text |
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Summary: | A synthetic approach to polyurethane cationomers containing S-pyroglutamyl-S-glutamic acid dipeptide (S-PyGlu-S-Glu) and alkylammonium groups is presented. Two segmented polycations,
based on polycaprolactone diol, isophorone diisocyanate and dipeptide together with N-methyldiethanolamine, subsequently quaternized with dodecylbromide, were synthesized and characterized by IR
spectroscopy, GPC, DSC and reduced viscosity measurements. Such polycations exhibited excellent film forming properties and their soft elastomeric nature provides adequate physical properties. Optical rotation
varying from +10 (monomer) to -15 (polycation) could be associated with a configuration pertubation through the asymmetric carbon atoms of glutamic residues. Susceptibility of the cationic surface to heparinization
and then to blood-polymer interaction suggested an anticoagulant activity of the heparinized polymeric films. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0920-5063 1568-5624 |
DOI: | 10.1163/156856204774196162 |