Epigenetic Associations between lncRNA/circRNA and miRNA in Hepatocellular Carcinoma

The three major members of non-coding RNAs (ncRNAs), named microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in hepatocellular carcinoma (HCC) development. Recently, the competing endogenous RNA (ceRNA) regulation model described lncRNA/circRNA...

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Published inCancers Vol. 12; no. 9; p. 2622
Main Authors Han, Tae-Su, Hur, Keun, Cho, Hyun-Soo, Ban, Hyun Seung
Format Journal Article
LanguageEnglish
Published MDPI AG 01.09.2020
MDPI
Subjects
circular RNA
competing endogenous RNA
Epigenetic inheritance
Genetic aspects
Health aspects
Hepatocellular carcinoma
long non-coding RNA
Methods
MicroRNA
Review
RNA sequencing
United States
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Summary:The three major members of non-coding RNAs (ncRNAs), named microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in hepatocellular carcinoma (HCC) development. Recently, the competing endogenous RNA (ceRNA) regulation model described lncRNA/circRNA as a sponge for miRNAs to indirectly regulate miRNA downstream target genes. Accumulating evidence has indicated that ceRNA regulatory networks are associated with biological processes in HCC, including cancer cell growth, epithelial to mesenchymal transition (EMT), metastasis, and chemoresistance. In this review, we summarize recent discoveries, which are specific ceRNA regulatory networks (lncRNA/circRNA-miRNA-mRNA) in HCC and discuss their clinical significance.
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These authors contributed equally to this work.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12092622