Application of traditional Chinese medicine preparation in targeting drug delivery system

• Published in: Drug delivery Vol. 22; no. 3; pp. 258 - 265
• Main Authors: Xu, Wei, Xing, Feng J., Dong, Kai, You, Cuiyu, Yan, Yan, Zhang, Lu, Zhao, Guilan, Chen, Youliang, Wang, Ke
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare USA, Inc 01.05.2015; Informa Healthcare
• Subjects: Biological Transport; Clinical treatments; Drug Carriers - chemistry; Drug Delivery Systems - methods; Drug Delivery Systems - trends; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - pharmacokinetics; Emulsions; Humans; Liposomes; Microspheres; Nanoparticles; Particle Size; pharmacological effects; Surface Properties; targeting drug delivery system; TCM-targeted preparations; traditional Chinese medicine; traditional Chinese medicine; TCM-targeted preparations; targeting drug delivery system; Clinical treatments; pharmacological effects
• ISSN: 1071-7544; 1521-0464
• DOI: 10.3109/10717544.2014.892545

Abstract Targeting drug system (TDS) or targeted drug delivery system (TDDS) is a new kind of drug delivery system which could make drug to be directly concentrated on the target site with high curative effects and low side-effects. As the quintessence of Chinese culture, traditional Chinese medicine (TCM) has a large advantage in many disease clinical treatments, especially in cancer, hypertension and many other intractable diseases owing to their low toxicity and side-effects relative to western medicine. This article reviews literatures on development of TCM-targeted preparations which were published in the past 10 years. TDS including active-targeting, passive-targeting and physical-chemical-targeting preparations were introduced through domestic and overseas literatures to reveal the unique advantages of TCM-targeting preparations in drug delivery system. In this article, we have reviewed some kinds of TCM-targeting preparations and indicated that great attention should be paid to the research on the TCM-targeting preparations.