Clinical isolate of vancomycin-heterointermediate Staphylococcus aureus susceptible to methicillin and in vitro selection of a vancomycin-resistant derivative
A Staphylococcus aureus strain with low-level heteroresistance to vancomycin (designated MER) but susceptible to methicillin was isolated from an outpatient with conjunctivitis who did not receive any glycopeptide antibiotics. Incubation of the parent strain, MER, with increasing concentrations of v...
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Published in | Antimicrobial agents and chemotherapy Vol. 45; no. 1; pp. 349 - 352 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Society for Microbiology
2001
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Series | Note |
Subjects | |
Online Access | Get full text |
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Summary: | A Staphylococcus aureus strain with low-level heteroresistance to vancomycin (designated MER) but susceptible to methicillin was isolated from an outpatient with conjunctivitis who did not receive any glycopeptide antibiotics. Incubation of the parent strain, MER, with increasing concentrations of vancomycin led to rapid selection of a stable progeny homogeneously resistant to vancomycin. Electron micrographs of strain MER showed enhanced cell wall thickness and abnormal septations typically seen with methicillin-resistant S. aureus having intermediate susceptibility to vancomycin. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3 Corresponding author. Mailing address: Laboratoire de Microbiologie, EA 1655, Hôpital Edouard Herriot, 5 Place d'Arsonval. 69437 Lyon cedex 03, France. Phone: 33 (0) 472 11 05 94. Fax: 33 (0) 472 11 07 64. E-mail: jetienne@univ-lyon1.fr. |
ISSN: | 0066-4804 1098-6596 |
DOI: | 10.1128/AAC.45.1.349-352.2001 |