Clinical isolate of vancomycin-heterointermediate Staphylococcus aureus susceptible to methicillin and in vitro selection of a vancomycin-resistant derivative

A Staphylococcus aureus strain with low-level heteroresistance to vancomycin (designated MER) but susceptible to methicillin was isolated from an outpatient with conjunctivitis who did not receive any glycopeptide antibiotics. Incubation of the parent strain, MER, with increasing concentrations of v...

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Published inAntimicrobial agents and chemotherapy Vol. 45; no. 1; pp. 349 - 352
Main Authors BOBIN-DUBREUX, Sophie, REVERDY, Marie-Elisabeth, NERVI, Chantal, ROUGIER, Martine, BOLMSTRÖM, Anne, VANDENESCH, Francois, ETIENNE, Jerome
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 2001
SeriesNote
Subjects
Adult
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Conjunctivitis - microbiology
Female
Humans
Mechanisms of Resistance
Medical sciences
Methicillin - pharmacology
Penicillins - pharmacology
Pharmacology. Drug treatments
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - isolation & purification
Staphylococcus aureus - ultrastructure
Vancomycin - pharmacology
Vancomycin Resistance
Human
Microorganism growth
Peptides
β-Lactams
Conjunctiva disease
Conjunctivitis
Vancomycin
In vitro
Teicoplanin
Meticillin
Penicillin derivatives
Resistance
Eye disease
Antibiotic
Glycopeptide
Minimum inhibitory concentration
Bacteria
Micrococcales
Micrococcaceae
Antibacterial agent
Staphylococcus aureus
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Summary:A Staphylococcus aureus strain with low-level heteroresistance to vancomycin (designated MER) but susceptible to methicillin was isolated from an outpatient with conjunctivitis who did not receive any glycopeptide antibiotics. Incubation of the parent strain, MER, with increasing concentrations of vancomycin led to rapid selection of a stable progeny homogeneously resistant to vancomycin. Electron micrographs of strain MER showed enhanced cell wall thickness and abnormal septations typically seen with methicillin-resistant S. aureus having intermediate susceptibility to vancomycin.
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Corresponding author. Mailing address: Laboratoire de Microbiologie, EA 1655, Hôpital Edouard Herriot, 5 Place d'Arsonval. 69437 Lyon cedex 03, France. Phone: 33 (0) 472 11 05 94. Fax: 33 (0) 472 11 07 64. E-mail: jetienne@univ-lyon1.fr.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.45.1.349-352.2001