What is the real shape of extracellular spikes?

We show that the standard filters used for on-line spike detection in most hardware acquisition systems introduce distortions in the recorded spike shapes. This is because on-line spike detection is done after band pass filtering the data with causal filters. As illustrated with three clusters of sp...

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Bibliographic Details
Published inJournal of neuroscience methods Vol. 177; no. 1; pp. 194 - 198
Main Author Quian Quiroga, R.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.02.2009
Subjects
Action Potentials - physiology
Electroencephalography - methods
Extracellular Space - physiology
Filtering
Humans
Single cell recordings
Spike detection
Spike sorting
Spikes
Temporal Lobe - physiology
Time Factors
Spikes
Spike sorting
Spike detection
Filtering
Single cell recordings
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Summary:We show that the standard filters used for on-line spike detection in most hardware acquisition systems introduce distortions in the recorded spike shapes. This is because on-line spike detection is done after band pass filtering the data with causal filters. As illustrated with three clusters of spike shapes from a real single cell recording in a human subject, causal filtering can create a spurious negative rebound and a smooth looking appearance of the spikes. We also show that these filtering distortions can make artifacts look similar to real spikes.
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ISSN:0165-0270
1872-678X
DOI:10.1016/j.jneumeth.2008.09.033