Renal effects of uric acid: hyperuricemia and hypouricemia

The prevalence of chronic kidney disease (CKD) is increasing worldwide. Although hyperuricemia has been associated with CKD in many studies, it remains controversial whether this is the cause or the result of decreased renal function. Recent observational studies of healthy populations and patients...

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Published inThe Korean journal of internal medicine Vol. 35; no. 6; pp. 1291 - 1304
Main Authors Park, Jung Hwan, Jo, Yong-Il, Lee, Jong-Ho
Format Journal Article
LanguageEnglish
Published The Korean Association of Internal Medicine 01.11.2020
대한내과학회
Subjects
hyperuricemia
hypouricemia
kidney
Review
uric acid
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Summary:The prevalence of chronic kidney disease (CKD) is increasing worldwide. Although hyperuricemia has been associated with CKD in many studies, it remains controversial whether this is the cause or the result of decreased renal function. Recent observational studies of healthy populations and patients with CKD have reported that uric acid (UA) has an independent role in the development or progression of CKD. Experimental studies have shown several potential mechanisms by which hyperuricemia may cause or promote CKD. However, other reports have indicated an association between hypouricemia and CKD. This opposing effect is hypothesized to occur because UA is a major antioxidant in human plasma and is associated with oxidative stress. In this article, we discuss the potential association between UA imbalance and CKD and how they can be treated.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1226-3303
2005-6648
DOI:10.3904/kjim.2020.410