Golgi pH, its regulation and roles in human disease

Most organelles within the exocytic and endocytic pathways typically acidify their interiors, a phenomenon that is known to be crucial for their optimal functioning in eukaryotic cells. This review highlights recent advances in our understanding of how Golgi acidity is maintained and regulated, and...

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Published inAnnals of medicine (Helsinki) Vol. 44; no. 6; p. 542
Main Authors Rivinoja, Antti, Pujol, Francois M, Hassinen, Antti, Kellokumpu, Sakari
Format Journal Article
LanguageEnglish
Published England 01.09.2012
Subjects
Cutis Laxa - etiology
Cutis Laxa - physiopathology
Cystic Fibrosis - etiology
Cystic Fibrosis - physiopathology
Disease - etiology
Endocytosis - physiology
Eukaryotic Cells - metabolism
Eukaryotic Cells - physiology
Exocytosis - physiology
Glycosylation
Golgi Apparatus - metabolism
Golgi Apparatus - physiology
Humans
Hydrogen-Ion Concentration
Neoplasms - etiology
Neoplasms - physiopathology
Organelles - metabolism
Organelles - physiology
Pemphigus, Benign Familial - etiology
Pemphigus, Benign Familial - physiopathology
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Summary:Most organelles within the exocytic and endocytic pathways typically acidify their interiors, a phenomenon that is known to be crucial for their optimal functioning in eukaryotic cells. This review highlights recent advances in our understanding of how Golgi acidity is maintained and regulated, and how its misregulation contributes to organelle dysfunction and disease. Both its biosynthetic products (glycans) and protein-sorting events are highly sensitive to changes in Golgi luminal pH and are affected in certain human disease states such as cancers and cutis laxa. Other potential disease states that are caused by, or are associated with, Golgi pH misregulation will also be discussed.
ISSN:1365-2060
DOI:10.3109/07853890.2011.579150