Prophylaxis and Treatment of Chagas Disease in Renal Transplant Donor and Recipient: Case Report

• Published in: Transplantation proceedings Vol. 42; no. 1; pp. 393 - 394
• Main Authors: Ortiz, A.M, Troncoso, P, Sainz, M, Vilches, S
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 2010; Elsevier
• Subjects: Adult; Anti-Infective Agents - therapeutic use; Biological and medical sciences; Chagas Disease - complications; Chagas Disease - drug therapy; Chagas Disease - prevention & control; Chagas Disease - transmission; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Histocompatibility Testing; HLA-A Antigens - immunology; HLA-B Antigens - immunology; HLA-DR Antigens - immunology; Humans; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - surgery; Kidney Transplantation - immunology; Living Donors; Male; Medical sciences; Middle Aged; Nitrofurazone - therapeutic use; Polymerase Chain Reaction; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Suboptimal donor; Human; Protozoal disease; Chagas disease; Transplantation; Parasitosis; Homotransplantation; Kidney; Infection; Case study; Medicine; Prevention; Treatment; Urinary system; Surgery; Graft; Trypanosomiasis
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2009.11.014

Abstract Chagas disease is a prevalent zoonosis in Latin America, caused by the protozoa Trypanosoma cruzi and transmitted by Triatoma infestans. Part of the infectious cycle consists of chronic subclinical parasitemia, causing in the long term end-organ damage. Amastigotes have been isolated from various organs including native and allograft renal parenchyma; thus, transplantation plus immunosuppression therapy is another mode of disease transmission and reactivation. Herein, we report 2 successful kidney transplantations cases in which either infection or reactivation was averted using prophylactic nitroderivates.