Mutational spectrum of N-hydroxy-N-acetyl-4-aminobiphenyl at exon 3 of the HPRT gene

• Published in: Biomarkers Vol. 6; no. 4; pp. 262 - 273
• Main Authors: ZAYAS-RIVERA, Beatriz, LIFANG ZHANG, GRANT, Stephen G, KEOHAVONG, Phouthone, DAY, Billy W
• Format: Journal Article
• Language: English
• Published: London Informa UK Ltd 2001; Taylor & Francis
• Subjects: Biological and medical sciences; Chemical mutagenesis; Hprt Aminobiphenyl Denaturant Gradient Gel Electrophoresis Mutational Spectrum; Medical sciences; Toxicology; Human; Enzyme; Metabolite; Toxicity; Preservation agent; Transferases; Glycosyltransferases; Hypoxanthine phosphoribosyltransferase; Mutagen; Metabolism; In vitro; Site of action; Exon; Biphenyl derivatives; Mutation; Pentosyltransferases; Biphenyl-4-ylamine

4-Aminobiphenyl is a human bladder carcinogen present in many environmental sources, including cigarette smoke. It can be metabolized in two steps to the mutagen N-hydroxy-N-acetyl-4-aminobiphenyl (N-OH-AABP). In this study the mutational spectrum of N-OH-AABP-exposed human lymphoblastoid cells (TK6...