Mutational spectrum of N-hydroxy-N-acetyl-4-aminobiphenyl at exon 3 of the HPRT gene

4-Aminobiphenyl is a human bladder carcinogen present in many environmental sources, including cigarette smoke. It can be metabolized in two steps to the mutagen N-hydroxy-N-acetyl-4-aminobiphenyl (N-OH-AABP). In this study the mutational spectrum of N-OH-AABP-exposed human lymphoblastoid cells (TK6...

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Bibliographic Details
Published inBiomarkers Vol. 6; no. 4; pp. 262 - 273
Main Authors ZAYAS-RIVERA, Beatriz, LIFANG ZHANG, GRANT, Stephen G, KEOHAVONG, Phouthone, DAY, Billy W
Format Journal Article
LanguageEnglish
Published London Informa UK Ltd 2001
Taylor & Francis
Subjects
Biological and medical sciences
Chemical mutagenesis
Hprt Aminobiphenyl Denaturant Gradient Gel Electrophoresis Mutational Spectrum
Medical sciences
Toxicology
Human
Enzyme
Metabolite
Toxicity
Preservation agent
Transferases
Glycosyltransferases
Hypoxanthine phosphoribosyltransferase
Mutagen
Metabolism
In vitro
Site of action
Exon
Biphenyl derivatives
Mutation
Pentosyltransferases
Biphenyl-4-ylamine
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Summary:4-Aminobiphenyl is a human bladder carcinogen present in many environmental sources, including cigarette smoke. It can be metabolized in two steps to the mutagen N-hydroxy-N-acetyl-4-aminobiphenyl (N-OH-AABP). In this study the mutational spectrum of N-OH-AABP-exposed human lymphoblastoid cells (TK6) was determined using HPRT
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1354-750X
1366-5804
DOI:10.1080/13547500010017367