Common Variants of Hepatocyte Nuclear Factor 1β Are Associated With Type 2 Diabetes in a Chinese Population

• Published in: Diabetes (New York, N.Y.) Vol. 58; no. 4; pp. 1023 - 1027
• Main Authors: Wang, Congrong, Hu, Cheng, Zhang, Rong, Bao, Yuqian, Ma, Xiaojing, Lu, Jingyi, Qin, Wen, Shao, Xinyu, Lu, Junxi, Xu, Jing, Lu, Huijuan, Xiang, Kunsan, Jia, Weiping
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.04.2009
• Subjects: Biological and medical sciences; Brief Reports; Diabetes. Impaired glucose tolerance; DNA binding proteins; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Genetic aspects; Genetic variation; Health aspects; Medical sciences; Risk factors; Type 2 diabetes; China; Endocrinopathy; Type 2 diabetes; Variant; Hepatocyte; Digestive system; Liver; Metabolic diseases; Chinese
• ISSN: 0012-1797; 1939-327X
• DOI: 10.2337/db08-1064

Common Variants of Hepatocyte Nuclear Factor 1β Are Associated With Type 2 Diabetes in a Chinese Population Congrong Wang , Cheng Hu , Rong Zhang , Yuqian Bao , Xiaojing Ma , Jingyi Lu , Wen Qin , Xinyu Shao , Junxi Lu , Jing Xu , Huijuan Lu , Kunsan Xiang and Weiping Jia Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China. Corresponding author: Weiping Jia, wpjia{at}sjtu.edu.cn . C.W. and C.H. contributed equally to this article. Abstract OBJECTIVE Hepatocyte nuclear factor 1β (HNF1β) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis. Previous studies have reported that common variants of HNF1 β were associated with type 2 diabetes in Caucasians and West Africans. However, analysis in the subjects from the Botnia study and Malmö Preventive Project produced conflicting results, and the role for HNF1 β in type 2 diabetes susceptibility remains unclear. We therefore investigated common variants across the HNF1 β gene in a Chinese population. RESEARCH DESIGN AND METHODS Fifteen tagging single nucleotide polymorphisms (SNPs) were analyzed for association with type 2 diabetes in subjects with type 2 diabetes ( n = 1,859) and normal glucose regulation ( n = 1,785). RESULTS Consistent with the initial study, we observed evidence that the risk G allele of rs4430796 in intron 2 was significantly associated with type 2 diabetes (odds ratio 1.16 [95% CI 1.05–1.29], P = 0.0035, empirical P = 0.0475). Furthermore, the at-risk G allele was associated with earlier age at diagnosis in the type 2 diabetic subjects ( P = 0.0228). CONCLUSIONS The result of this study provides evidence that variants in the HNF1 β region contribute to susceptibility to type 2 diabetes in the Chinese population. Footnotes The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Received August 4, 2008. Accepted January 13, 2009. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. © 2009 by the American Diabetes Association.