DISODIUM D-6-[α-(1, 2, 4-TRIAZINE-3, 5-DIONE-6-CARBOXAMIDO)- 4-HYDROXYPHENYLACETAMIDO]PENICILLANATE, BL-P1908

The synthesis of a new penicillin, disodium D-6-[α-(1, 2, 4-triazine-3, 5-dione-6-carboxamido)-4-hydroxyphenylacetamido]penicillanate (BL-P1908), is described. The compound shows superior in vitro activity against Pseudomonas aeruginosa compared to carbenicillin and ticarcillin and produces higher i...

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Published inJournal of antibiotics Vol. 32; no. 5; pp. 468 - 471
Main Authors BAKER, STEPHEN R., HOLDREGE, CHARLES T., MCGREGOR, DONALD N.
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1979
Subjects
Animals
Chemical Phenomena
Chemistry
Chemistry, Physical
Mice
Penicillin Resistance
Penicillins - blood
Penicillins - chemical synthesis
Penicillins - pharmacology
Pseudomonas aeruginosa - drug effects
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Summary:The synthesis of a new penicillin, disodium D-6-[α-(1, 2, 4-triazine-3, 5-dione-6-carboxamido)-4-hydroxyphenylacetamido]penicillanate (BL-P1908), is described. The compound shows superior in vitro activity against Pseudomonas aeruginosa compared to carbenicillin and ticarcillin and produces higher intramuscular serum levels in mice than does carbenicillin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.32.468