Electrochemical Detector for High-Performance Liquid Chromatography. VI. Application of a Twin Electrochemical Detector

The fundamental characteristics of a twin electrochemical detector were evaluated to investigate its suitability as a detector for high-performance liquid chromatography. This novel detector was proved to have the following advantages compared to the conventional three-electrode detector. 1) Simulta...

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Published inChemical & pharmaceutical bulletin Vol. 31; no. 10; pp. 3571 - 3578
Main Authors HIROSHIMA, OSAMU, IKENOYA, SATORU, NAITOH, TOSHIHIKO, KUSUBE, KENICHI, OHMAE, MASAHIKO, KAWABE, KIYOSHI, ISHIKAWA, SEIJI, HOSHIDA, HARUHIKO, KURAHASHI, TATSUO
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1983
Maruzen
Japan Science and Technology Agency
Subjects
Analytical chemistry
Chemistry
Exact sciences and technology
General, instrumentation
monoamine
High performance
Chemical analysis
Biological medium
Instrumentation
Liquid chromatography
Catecholamine
Electrochemical detector
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Summary:The fundamental characteristics of a twin electrochemical detector were evaluated to investigate its suitability as a detector for high-performance liquid chromatography. This novel detector was proved to have the following advantages compared to the conventional three-electrode detector. 1) Simultaneous determination of reduced and oxidized species is possible, 2) the stability of the electrode is improved by applying a larger potential to the other electrode, 3) the specificity of detection is improved by the re-electrolysis at the second electrode of the reaction product produced at the first electrode, and 4) specific detection of the post-discharging materials and sensitive detection are possible by using appropriate operating circuits.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.31.3571