Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes

The different mechanisms employed by proto-oncogenes and tumor suppressors to regulate cell death pathways are strictly linked to their localization. In addition to the canonical control of apoptosis at a transcriptional/nuclear level, intracellular zones are emerging as pivotal sites for the activi...

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Published inMolecular & cellular oncology Vol. 1; no. 2; p. e956469
Main Authors Marchi, Saverio, Giorgi, Carlotta, Oparka, Monika, Duszynski, Jerzy, Wieckowski, Mariusz R, Pinton, Paolo
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 16.06.2014
Subjects
apoptosis
calcium
cancer
endoplasmic reticulum
mitochondria
mitochondria-associated membranes (MAMs)
oncogenes
oncosuppressors
Review
calcium
mitochondria-associated membranes (MAMs)
mitochondria
oncogenes
apoptosis
cancer
oncosuppressors
endoplasmic reticulum
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Summary:The different mechanisms employed by proto-oncogenes and tumor suppressors to regulate cell death pathways are strictly linked to their localization. In addition to the canonical control of apoptosis at a transcriptional/nuclear level, intracellular zones are emerging as pivotal sites for the activities of several proapoptotic and antiapoptotic factors. Here, we review the function of the endoplasmic reticulum-mitochondria interface as a primary platform for decoding danger signals as well as a structural accommodation for several regulator or effector proteins.
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These authors contributed equally to this work.
ISSN:2372-3556
2372-3548
2372-3556
DOI:10.4161/23723548.2014.956469