Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses

Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human b...

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Bibliographic Details
Published inNature neuroscience Vol. 9; no. 1; pp. 23 - 25
Main Authors Fox, Michael D, Snyder, Abraham Z, Zacks, Jeffrey M, Raichle, Marcus E
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.01.2006
Subjects
Brain
Brain - physiology
Evoked Potentials - physiology
Humans
Magnetic Resonance Imaging
Medical examination
Oxygen - blood
Photic Stimulation
Physiological aspects
Psychomotor Performance - physiology
Reproducibility of Results
United States
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Summary:Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity account for a significant fraction of the variability in measured event-related BOLD responses and that spontaneous and task-related activity are linearly superimposed in the human brain.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1097-6256
1546-1726
DOI:10.1038/nn1616