Directly Bactericidal Anti-Escherichia coli Antibody

Monoclonal antibodies are considered promising therapeutic alternatives to fight antibiotic-resistant bacteria. Upon binding to their targets, they either act alone (e.g., by neutralizing bacterial toxins) or in concert with the host’s immune system (with complement or phagocytes). Storek et al. hav...

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Bibliographic Details
Published inTrends in microbiology (Regular ed.) Vol. 26; no. 8; pp. 642 - 644
Main Authors Szijártó, Valéria, Nagy, Eszter, Nagy, Gábor
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2018
Elsevier Science Ltd
Subjects
Antibiotic resistance
Antibiotics
bacteria
bacterial toxins
bactericidal activity
complement
Drug resistance
E coli
Escherichia coli
Immune system
Medicine
Monoclonal antibodies
monoclonal antibody
neutralization
phagocytes
therapeutics
bactericidal activity
monoclonal antibody
Escherichia coli
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Summary:Monoclonal antibodies are considered promising therapeutic alternatives to fight antibiotic-resistant bacteria. Upon binding to their targets, they either act alone (e.g., by neutralizing bacterial toxins) or in concert with the host’s immune system (with complement or phagocytes). Storek et al. have described a unique, directly bactericidal antibody against Escherichia coli.
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ISSN:0966-842X
1878-4380
1878-4380
DOI:10.1016/j.tim.2018.05.016