Green factory: Plants as bioproduction platforms for recombinant proteins

• Published in: Biotechnology advances Vol. 30; no. 5; pp. 1171 - 1184
• Main Authors: Xu, Jianfeng, Dolan, Maureen C., Medrano, Giuliana, Cramer, Carole L., Weathers, Pamela J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.09.2012
• Subjects: aquatic plants; Bioreactors; Biotechnology - economics; Biotechnology - methods; cell suspension culture; Cells, Cultured; Commerce; Duckweed; Hairy roots; Humans; industry; Microalgae; Molecular farming; Moss; Plant cell culture; plant tissues; Plant-made recombinant proteins; Plants - metabolism; recombinant proteins; Recombinant Proteins - biosynthesis; Recombinant Proteins - classification; Recombinant Proteins - economics; roots; Transgenic plants; veterinary medicine; Molecular farming; Duckweed; Plant cell culture; Moss; Microalgae; Plant-made recombinant proteins; Transgenic plants; Hairy roots
• ISSN: 0734-9750; 1873-1899
• DOI: 10.1016/j.biotechadv.2011.08.020

Molecular farming, long considered a promising strategy to produce valuable recombinant proteins not only for human and veterinary medicine, but also for agriculture and industry, now has some commercially available products. Various plant-based production platforms including whole-plants, aquatic plants, plant cell suspensions, and plant tissues (hairy roots) have been compared in terms of their advantages and limits. Effective recombinant strategies are summarized along with descriptions of scalable culture systems and examples of commercial progress and success.