Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction

Genetic variation may partially underlie complex personality and physiological traits--such as impulsivity, risk taking and stress responsivity--as well as a substantial proportion of vulnerability to addictive diseases. Furthermore, personality and physiological traits themselves may differentially...

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Bibliographic Details
Published inNature neuroscience Vol. 8; no. 11; pp. 1450 - 1457
Main Authors Kreek, Mary Jeanne, Nielsen, David A, Butelman, Eduardo R, LaForge, K Steven
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.11.2005
Subjects
Alcoholism
Animals
Comorbidity
Costs
Drug abuse
Drug addiction
Drug use
Genetic aspects
Genetic Variation
Genetics
Health aspects
Humans
Impulsive Behavior - genetics
Impulsivity
Influence
Models, Biological
Neurosciences
Personality
Personality - genetics
Physiological aspects
Physiology
Proteins
Risk factors
Risk-Taking
Stress, Physiological - genetics
Substance-Related Disorders - epidemiology
Substance-Related Disorders - genetics
Substance-Related Disorders - physiopathology
Vulnerability (Psychology)
United States
New York
United States > US
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Summary:Genetic variation may partially underlie complex personality and physiological traits--such as impulsivity, risk taking and stress responsivity--as well as a substantial proportion of vulnerability to addictive diseases. Furthermore, personality and physiological traits themselves may differentially affect the various stages of addiction, defined chronologically as initiation of drug use, regular drug use, addiction/dependence and potentially relapse. Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases.
ISSN:1097-6256
1546-1726
DOI:10.1038/nn1583